If you don't know what Nuzlocke is, it's basically hard mode on Pokemon. Since Pokemon is generally easy, this self-challenge that makes it more fun.
What you have to do in order to "Nuzlocke":
You may only catch the first Pokemon in a new area.
Any of your Pokemon that faints is dead.
Not an official rule but, nickname all of the Pokemon you catch, makes it much more fun for you and you get attached to them more easily.
Now let me expand on those rules since some of you might not get it:
The first rule defines a new area as a new route/city. Lets say you encounter your first Pokemon in that new area, you accidently kill it in the process of catching it, too bad you cannot catch anymore Pokemon in that area, or that you don't have any Pokeballs, too bad you'll have to kill or run away from it and you cannot catch anymore Pokemon in that area. Trading/fishing is also considered okay, but that will be your first Pokemon in that area, if you already got a Pokemon in that area and meet a NPC trader, you cannot trade a for that Pokemon.
Second rule is really simple, your Pokemon faints? It's dead forever, this makes it more realistic, lets say your Charmander has died while facing a Pikachu, well you cannot use Charmander anymore! You can either set the Pokemon free, or put it in a PC box labelled "Dead", etc. Either way fainted = dead, and you cannot simply revive them by going to the PokeCenter anymore.
Third rule is just for fun, makes it much more attached to your Pokemon, so if that Pokemon dies, you'll probably die a little bit on the inside too.
Oh I would also like to add that excessive grinding is frowned upon when doing a Nuzlocke grind, even though it is Pokemon and you do have to grind sometimes, excessively doing it makes it easier which basically blows away the whole meaning of doing a Nuzlocke run. :]
So yeah that's the rules for Nuzlocke run, basically I'm starting it right now. I just pulled out my old Leaf Green and started playing it with Nuzlocke rules. Hope I'm not the only one. owo; I've searched and there weren't any threads on this, so I think this is the only one, yes? No? Magical ponies?
Just get an emulator and ROM for it if you want to test it and you can't find your old GBA or whatever. e________e; My Charmander almost died on the second battle with a Ratata, critical hits suck. At least I got a Potion from the PokeMart guy that's giving out free samples.