I'm pretty sure there are several ways you can play a instrument in real life.
First ones to come to my mind is Guitars. There are left and right handed versions. How you hold them is reversed. So why wouldn't there be the same for other instruments as well?
Edit:
No the violin is always in your left hand the bow in your right.
http://www.youtube.com/watch?v=HhXQho--DlE
Yeah. You can hold a violin left handedly. And that is what they did with Mabi.