I've tried to hybrid magic with pretty much every talent over the years, but I still find that magic + magic works the best. Now you can use guard cylinders with wands, so the 'support' side of alchemy works fairly well too. I personally like to use:
Savage Ice Wand + Holy Eagle Mask (Blaze unfortunately does not benefit from the shields mana reduction)
Ego Fire Wand + Guard Cylinder (I choose to let the fire wand go without the holy eagle mask because firebolt doesn't benefit nearly as much from MATK)
This allows full use of the following skills:
- Firebolt (Chaincast)
- Ice Spear
- Blaze
- Life Drain
- Rain Casting
Also wind blast, shockwave, fusion/normal bolts, sand burst, barrier spikes. Of course it never hurts to use Counterattack, Windmill, Charge, Defense, Vivace, Lullaby. It might be hard to hotkey all of these skills though.